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Amitraz Data, Including Safety Data

The molecular structure of Amitraz...

Disclaimer! This information has been compiled from many sources... But does not in any way replace or supersede the information on the acaricide product label, instruction sheet or other regulatory requirements. Please refer to the particular product label. The information is presented here in good faith, but I am not responsible for it's ultimate accuracy.

Physical Properties
Appearance... White or yellowish crystalline solid. Or yellowish to orange liquid
Melting point... 86 - 87°C.
Solubility... Slightly soluble in water. Soluble in common organic solvents.
pH value... 9.0 - 10.5
Purity... This can vary widely ( 98% to 20% )

Chemical Properties
Formula... C₁₉H₂₃N₃
Molecular Weight... 293.33
Composition... N-(2,4-dimethylphenyl)-N-[[(2,4-dimethylphenyl)imino]methyl]-N-methylmethanimidamide; N-methylbis(2,4-xylyliminomethyl)amine.
The molecular structure of Amitraz...
Uses
Amitraz is used as an acaricide to control varroa infestations in honey bees.
As an insecticide on fruit trees and other horticultural crops, where it controls...
pear psylla on pears, whitefly on cotton, tetranychid and eriophyid mites on fruit, citrus, ornamental, and other crops, and it controls both eggs and neonate larvae of cotton bollworm as well as tobacco budworm.
It is also used against pests in mammalian domestic pets where it controls ticks and mange mites. Similarly it controls lice on cattle and pigs.
It is used as a synergist to other insecticides.

Hazards
Amitraz is an alpha-2 agonist.

Clinical symptoms
30 minutes to 2 hours after ingestion...
GI disturbance: nausea, vomiting
Respiratory and CNS depression (drowsiness, coma)
Bradycardia, hypotension, hypothermia
Hyperglycaemia
Rise in liver enzyme activity (transaminases)

Recovery
CNS depression resolves within 18 hours, other signs and symptoms subside within 24 to 48 hours.

Treatment
Stomach washing may be considered.

Supportive care
Intubation and assisted ventilation may be required.
Dobutamine hydrochloride may be considered to counteract hypotension and slightly raise heart rate.

Environmental Hazards
Fish... LD50 0.74 ppm (rainbow trout), 0.5 ppm (bluegill).
Bee... Nontoxic.
Bird... Oral LD50 788 mg/kg (bobwhite). Dietary LD50 7000 ppm (mallard).

Toxicity
Rat... Oral LD50 650 mg/kg. Dermal LD50 >1600 mg/kg.
Rabbit... Dermal LD50 >200 mg/kg.

Recommended Protective Clothing
Tightly woven long sleeved shirt and long trousers, nitrile rubber gloves, boots, face shield. Wear clean clothing every day, launder before re-using. Remove contaminated clothing immediately. Wash eyes with water. Wash other affected parts of body with soap and water. If the extent of contamination is unknown, bathe entire body thoroughly, change clothing.

Handling & Storage
Do not store at temperatures below 0°C. Avoid contact with eyes, skin, or clothing. Do not breathe mist, keep the container closed. Wash thoroughly after handling. Do not eat or smoke while handling, do not store with food or animal feeds.

Emergency Guidelines
Fire Extinguishing Media... Water, foam, dry powder, CO₂.
First Aid... Eyes, flush with water for at least 15 minutes. Get medical attention.
                  Skin, remove contaminated clothing and wash affected area with soap and water. Get medical attention.
                  Inhalation, remove to fresh air. Get medical attention.
                  Ingestion, rinse mouth with water. Keep patient at rest.

Originated... 25 October 2002, Revised... 24 April 2003