NAMES:
Adefovir Dipivoxil, bis POM PMEA, Preveon
TYPE OF DRUG:
An antiretroviral called a nucleotide analogue reverse transcriptase inhibitor, a fourth class of anti-HIV drugs.
STATUS:
Available through clinical trials in the UK. Research ongoing. Special access scheme likely in 1999.
EXPERIMENTAL DOSAGE:
60mg once a day.
TIPS ON TAKING:
Take with 500mg L-carnitine to reduce side-effects.
COMMON SIDE-EFFECTS:
Kidney abnormalities, neutropenia, nausea, vomiting, liver problems.
RESISTANCE:
Research ongoing. Test-tube studies suggest cross-resistance between adefovir and AZT, ddl and abacavir.
KEY DRUG INTERACTIONS:
Research ongoing. May require dose adjustment if taken with delavirdine.
RISK OF SIDE-EFFECTS:
increased if taken with isoniazid.
OTHER DRUGS IN THIS CLASS:
PMPA
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